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      "body": "<html> <p>https://cdn.steemitimages.com/DQmRqiqiQvrqgkD9DzAEwTkK28isUmfQV9qYFfzz8L5MTEx/image.png</p> <p><br></p> <p>Can you tell the smell of a rose from the scent of a lilac? If so, you have your brain's piriform cortex to thank. Compared to many parts of the brain, the piriform cortex -- which lets animals and humans process information about smells -- looks like a messy jumble of connections between cells called neurons. Now, Salk Institute researchers have illuminated how the randomness of the piriform cortex is actually critical to how the brain distinguishes between similar odors.</p> <p><br></p> <p>'<em>The standard paradigm is that information in the brain is encoded by which cells are active, but that's not true for the olfactory system</em>,' says Charles Stevens, Distinguished Professor Emeritus in Salk's Molecular Neurobiology Laboratory and coauthor of the new work. 'In the olfactory system, it turns out it's not a matter of which cells are active, but how many cells are active and how active they are.'</p> <p><br></p> <p>Aside from better understanding how smells are processed, the new research, published in the Journal of Comparative Neurology on July 17, 2018, could also lead to greater insight into how some parts of the brain organize information.</p> <p><br></p> <p>When odorant molecules -- the signature of any given smell -- bind to the receptors in a person's nose, the signal is transmitted to the olfactory bulb, and from there to the piriform cortex. In other sensory systems -- like the visual system -- information maintains a strict order as it moves through the brain. Particular parts of the eye, for instance, always transmit information to specific parts of the visual cortex. But researchers have long known that this order is missing in the piriform cortex.</p> <p><br></p> <p>'<em>We haven't been able to discern any order in the piriform cortex connections in any species</em>,' says coauthor Shyam Srinivasan, an assistant project scientist at the <a href='http://www.kavlifoundation.org/'>University of California San Diego's Kavli Institute for Brain and Mind.</a> '<em>Any given odor lights up about 10 percent of neurons that seem to be scattered all over the piriform cortex</em>.'</p> <p><br></p> <p>To start working out the details of how the piriform cortex encodes odor information -- and whether its connections are truly random -- Stevens and Srinivasan analyzed the piriform cortices of nine mice using a variety of staining and microscopy techniques that let them visualize different cell types in the brain region. Their first goal: to quantify the number and density of cells in the piriform cortex.</p> <p><br></p> <blockquote>'This was really like a survey,' explains Srinivasan. 'We counted the cells in different representative areas and averaged them across the whole region.'</blockquote> <p><br></p> <p>The mouse piriform cortex, they concluded, has around half a million neurons in it, divided equally between the larger, less dense posterior piriform and the smaller, more dense anterior piriform.</p> <p><br></p> <p>Using this initial information on density and neuron number, as well as knowledge from previous studies on the number of neurons in the olfactory bulb and how many neuronal connections -- or synapses -- connect the olfactory bulb to the piriform cortex, the pair of researchers was able to draw a surprising finding: each neuron in the olfactory bulb is connected to nearly every single neuron in the piriform cortex.</p> <p><br></p> <p>'<em>Every cell in the piriform is getting information from essentially every odor receptor there is</em>,' says Stevens. '<em>There's not one 'coffee smell' neuron but a whole bunch of coffee cell neurons all over the place.</em>' Rather than a single receptor detecting one odor and lighting up one cluster of telltale neurons, he explains, each odor has a fingerprint that's based more on the strength of the connections -- while the smell of coffee may activate nearly the same neurons in the piriform cortex as the smell of chocolate, they'll activate each neuron to a different degree.</p> <p><br></p> <blockquote>'One advantage to this system is that it can encode very complex information,' says Srinivasan. 'It also makes it very robust to noise.' If one neuron sends a 'noisy' signal -- stronger or weaker activation than it should -- the noise gets cancelled out by the many other neurons sending simultaneous, more accurate signals.</blockquote> <p><br></p> <p>The researchers would like to repeat the work in other animals to see where similarities and differences lie. They also are interested in looking into other areas of the brain that have long been assumed to be dominated by seemingly random connections to see if they're organized in the same way.</p> <p><br></p> <p>Stevens and Srinivasan, who also had a paper come out in the <a href='http://www.jneurosci.org/'>Journal of Neuroscience</a> on July 13 about using the fruit fly olfactory learning circuit to improve the current crop of deep learning algorithms, were funded by the Kavli Institute for Brain and Mind at UC San Diego and the <a href='http://www.nsf.org/'>National Science Foundation.</a></p> </html>",
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      "body": "<html> <p>https://cdn.steemitimages.com/DQmNnVBPKDXKjQrkWqTHivPDuKCe5dfX6HPvTbjMhWFfbaE/image.png</p> <p><br></p> <p>Wilder Wander’s free app, which launched earlier this summer, takes scientific data from research on biodiversity, space, the earth, oceans and weather patterns, and turns it into interactive, outdoor games.</p> <p>A scavenger hunt was designed by Wilder Wander for this bank holiday weekend’s All Together Now festival in Curraghmore House, Co Waterford.</p> <p>Founder Vicki O’Donnell describes the app as “like a mix between geocaching and orienteering”.</p> <p><br></p> <p>https://cdn.steemitimages.com/DQmPAVU1GWGiSMZWXSU2DhGUnZArJfv1yeh3UGxFod1gaUM/TWT.PNG</p> <p>It uses global positioning system (GPS) points to navigate different locations. Interactive games include content about natural history and heritage particular to an area and users can take part in quizzes and challenges. The app is linked back to maps and leaderboards on the website.</p> <p><br></p> <blockquote>It brings an extra dimension. It’s not like just a tour of somewhere; there’s some competition, as well</blockquote> <p>Ms O’Donnell studied zoology and worked in maritime research in UCC for a number of years.</p> <p>She was deployed by Irish Aid’s Rapid Response Corps and worked with the UN on emergency tool development.</p> <p>As an information specialist, she worked with NGOs to make sense of information “flying around at the beginning of emergencies” to find where the biggest needs were.</p> <p>She is applying that experience of transforming raw data into easily understood information for the Wilder Wander end-user.</p> <p>An example are large bird surveys carried out by BirdWatch Ireland. That data is put onto the National Biodiversity Data Centre’s database, and then onto a global data centre.</p> <p><br></p> <p>https://cdn.steemitimages.com/DQmRzXA17GpSJ8TGAnUMhUjXQBAPeRsXo8mB3bVbjc8HDVn/image.png</p> <p>Although this data is widely and publicly-available, there are problems with usability.</p> <p>Ms O’Donnell said much of the data uses the Latin names, is often in a grid format, and it’s not possible to see the exact location where a species was sighted.</p> <p>Wilder Wander aims to transform this “ugly data” to show people the wildlife around them and <em>what, potentially, should live all around them, if woodlands are protected.</em></p> <p>This will encourage users to be more aware of their environment and the importance of biodiversity. She said the app has the added benefit of getting people out and about and “throwing in a bit of exercise”.</p> <p>Children are <em>running around, playing games. It’s a really easy way to get them out moving, without them realising it.</em></p> <p>she said</p> <blockquote>People might say we don’t want kids outside with their devices. But some kids won’t go outside unless they have a device. That’s how many kids learn now</blockquote> <p>The third aspect to the platform is the reuse of scientific data. Ms O’Donnell said much of the data collected <em>sits on a shelf somewhere</em>. She referred to one statistic, which estimates that each data point that’s collected can cost up to 50 cent. With almost one billion data points in the world, that data is very expensive, she said.</p> <p>Another element to the app is the local history feature. Ms O’Donnell said that <em>people may have walked in an area for years, but didn’t realise such and such happened here.</em></p> <p>Ms O’Donnell took part in Enterprise Ireland’s New Frontiers Phase 2 programme, earlier this year, and was granted a stipend of €15,000, which allowed her to develop the company.</p> <p>The Wilder Wander app can be in different locations and reused again and again. It’s free for the end-user, with revenue coming from local councils, event and festival organisers, and wildlife and heritage organisations.</p> <p>The company is building a learning-management system for school and community groups, and a subscription model for training. Further potential uses are a citizen science tool to enable the public to collect data that can be linked to satellite imagery, to look at climate change.</p> <p><strong>While Wilder Wander is at an early stage, it has, however, its sights set on the global market.</strong></p> <p>The UK is a target, Ms O’Donnell said, as organisations such as the National Trust and other NGOs <em>would have a couple of million subscribers</em>.</p> </html>",
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