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      "body": "<html> <p>https://cdn.steemitimages.com/DQmNnVBPKDXKjQrkWqTHivPDuKCe5dfX6HPvTbjMhWFfbaE/image.png</p> <p><br></p> <p>Wilder Wander’s free app, which launched earlier this summer, takes scientific data from research on biodiversity, space, the earth, oceans and weather patterns, and turns it into interactive, outdoor games.</p> <p>A scavenger hunt was designed by Wilder Wander for this bank holiday weekend’s All Together Now festival in Curraghmore House, Co Waterford.</p> <p>Founder Vicki O’Donnell describes the app as “like a mix between geocaching and orienteering”.</p> <p><br></p> <p>https://cdn.steemitimages.com/DQmPAVU1GWGiSMZWXSU2DhGUnZArJfv1yeh3UGxFod1gaUM/TWT.PNG</p> <p>It uses global positioning system (GPS) points to navigate different locations. Interactive games include content about natural history and heritage particular to an area and users can take part in quizzes and challenges. The app is linked back to maps and leaderboards on the website.</p> <p><br></p> <blockquote>It brings an extra dimension. It’s not like just a tour of somewhere; there’s some competition, as well</blockquote> <p>Ms O’Donnell studied zoology and worked in maritime research in UCC for a number of years.</p> <p>She was deployed by Irish Aid’s Rapid Response Corps and worked with the UN on emergency tool development.</p> <p>As an information specialist, she worked with NGOs to make sense of information “flying around at the beginning of emergencies” to find where the biggest needs were.</p> <p>She is applying that experience of transforming raw data into easily understood information for the Wilder Wander end-user.</p> <p>An example are large bird surveys carried out by BirdWatch Ireland. That data is put onto the National Biodiversity Data Centre’s database, and then onto a global data centre.</p> <p><br></p> <p>https://cdn.steemitimages.com/DQmRzXA17GpSJ8TGAnUMhUjXQBAPeRsXo8mB3bVbjc8HDVn/image.png</p> <p>Although this data is widely and publicly-available, there are problems with usability.</p> <p>Ms O’Donnell said much of the data uses the Latin names, is often in a grid format, and it’s not possible to see the exact location where a species was sighted.</p> <p>Wilder Wander aims to transform this “ugly data” to show people the wildlife around them and <em>what, potentially, should live all around them, if woodlands are protected.</em></p> <p>This will encourage users to be more aware of their environment and the importance of biodiversity. She said the app has the added benefit of getting people out and about and “throwing in a bit of exercise”.</p> <p>Children are <em>running around, playing games. It’s a really easy way to get them out moving, without them realising it.</em></p> <p>she said</p> <blockquote>People might say we don’t want kids outside with their devices. But some kids won’t go outside unless they have a device. That’s how many kids learn now</blockquote> <p>The third aspect to the platform is the reuse of scientific data. Ms O’Donnell said much of the data collected <em>sits on a shelf somewhere</em>. She referred to one statistic, which estimates that each data point that’s collected can cost up to 50 cent. With almost one billion data points in the world, that data is very expensive, she said.</p> <p>Another element to the app is the local history feature. Ms O’Donnell said that <em>people may have walked in an area for years, but didn’t realise such and such happened here.</em></p> <p>Ms O’Donnell took part in Enterprise Ireland’s New Frontiers Phase 2 programme, earlier this year, and was granted a stipend of €15,000, which allowed her to develop the company.</p> <p>The Wilder Wander app can be in different locations and reused again and again. It’s free for the end-user, with revenue coming from local councils, event and festival organisers, and wildlife and heritage organisations.</p> <p>The company is building a learning-management system for school and community groups, and a subscription model for training. Further potential uses are a citizen science tool to enable the public to collect data that can be linked to satellite imagery, to look at climate change.</p> <p><strong>While Wilder Wander is at an early stage, it has, however, its sights set on the global market.</strong></p> <p>The UK is a target, Ms O’Donnell said, as organisations such as the National Trust and other NGOs <em>would have a couple of million subscribers</em>.</p> </html>",
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      "body": "<html> <p>https://cdn.steemitimages.com/DQmXRMuvbpicRvEZ3gfbkk3tvzgMqECRhp2C5b1RgEymk2N/image.png</p> <p><br></p> <p><strong>A small population of brain cells deep in a memory-making region of the brain controls the production of new neurons and may have a role in common brain disorders, according to a study from scientists at the University of North Carolina School of Medicine.</strong></p> <p><br></p> <p>The scientists, who published their work in Neuron, showed that 'mossy cells' in the hippocampus regulate local stem cells to control their production of new neurons, which is important for normal learning and memory, stress response, and mood regulation. Such neurogenesis in the adult brain is disrupted in many common conditions including Alzheimer's disease, depression, anxiety, schizophrenia, traumatic brain injury, and some forms of epilepsy. Targeting mossy cells to reverse such disruption may therefore offer a new strategy for treating these conditions.</p> <p><br></p> <p>'<strong>The hope is we could manipulate even a small number of mossy cells to restore hippocampal neurogenesis and related brain functions</strong>,' said study senior author Juan Song, <code>PhD</code>, assistant professor of pharmacology and member of the UNC Neuroscience Center.</p> <p><br></p> <p>Mossy cells are themselves a type of neuron and live in the part of the hippocampus known as the dentate gyrus, where neural stem cells also reside. These mossy cells -- and the nerve fibers that input various chemical signals to them -- earned their name because their multiple connection points give them a vaguely moss-covered appearance. Their precise functions have long been debated in part because they're not easy to distinguish from other brain cells. But mossy cells are known to be important for learning and memory and unusually sensitive to stresses. They die off quickly, for example, under the low-oxygen conditions of a stroke or heart attack, or when overstimulated by seizures in temporal lobe epilepsy.</p> <p><br></p> <p>Using advanced tracing techniques on several different strains of genetically engineered lab mice, Song and colleagues labeled mossy cells in mouse hippocampi and marked their connections to other brain cells. They found that mossy cells connected to neural stem cells directly and indirectly. These mossy cells directly communicate with stem cells in the hippocampus via an excitatory pathway. The mossy cells also indirectly communicate with stem cells through nearby neurons called interneurons that then connect to stem cells via an inhibitory pathway.</p> <p><br></p> <p>Surprisingly, Song and her team discovered that mossy cells can shift the balance of their direct and indirect signaling, thus dynamically regulating neural stem cell activity. In their experiments, Song's team found that moderate mossy cell activity, for example, resulted in the dominance of indirect signaling and kept stem cells in a '<strong>quiescent</strong>' state that may lead to a low level of neurogenesis, but the stem cells could be preserved over the long term. In contrast, high mossy cell activity, which could occur when the brain is stimulated or in a diseased state, made direct signaling dominant and kept stem cells in an 'activated' state that may lead to a high level of neurogenesis. But this may risk losing stem cells over the long term.</p> <p><br></p> <p>The scientists observed that removing a portion of mossy cells caused neural stem cells to increase their activity briefly followed by a permanent loss of stem cells. The finding hints that the abnormal loss of mossy cells may be a key factor underlying many pathological conditions where neurogenesis is deficient. This suggests replacing or otherwise altering the activity of these mossy cells could be a viable treatment strategy, according to Song.</p> <p><br></p> <p>The experiments also indicated that for mossy cells, a few cells go a long way. In a key set of experiments, the researchers were able to label only about a quarter of the mossy cell population. Yet by manipulating the activity level of these few cells, the scientists observed large changes in hippocampal stem cell activity and neurogenesis.</p> <p><br></p> <p>'<em>We were surprised that this small population of mossy cells could exert such a big impact on stem cell behavior</em>,' Song said.</p> <p><br></p> <p>Song and her team will now make use of the tools and lessons developed in this study to examine what happens to mossy cells in various disease states and how they might be replaced or have their activity altered to treat those diseases.</p> <p><br></p> <p><br></p> </html>",
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