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      "body": "<html> <p><strong>The diagnosis of diseases based in internal organs often relies on biopsy samples collected from affected regions. But collecting such samples is highly error-prone due to the inability of current endoscopic imaging techniques to accurately visualize sites of disease. The conventional optical elements in catheters used to access hard-to-reach areas of the body, such as the gastrointestinal tract and pulmonary airways, are prone to aberrations that obstruct the full capabilities of optical imaging.</strong></p> <p>https://cdn.steemitimages.com/DQmTi9yakaCojPokT75hJDqgFgAe34DwzTdVNANKN445gyi/image.png<br> </p> <p>Now, experts in endoscopic imaging at Massachusetts General Hospital (MGH) and pioneers of flat metalens technology at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), have teamed up to develop a new class of endoscopic imaging catheters -- termed nano-optic endoscopes -- that overcome the limitations of current systems.</p> <p><br></p> <p><strong>The research is described in Nature Photonics.</strong></p> <p>Clinical adoption of many cutting-edge endoscopic microscopy modalities has been hampered due to the difficulty of designing miniature catheters that achieve the same image quality as bulky desktop microscopes, said Melissa Suter, an assistant professor of Medicine at MGH and Harvard Medical School (HMS) and co-senior author of the paper. The use of nano-optic catheters that incorporate metalenses into their design will likely change the landscape of optical catheter design, resulting in a dramatic increase in the quality, resolution, and functionality of endoscopic microscopy. This will ultimately increase clinical utility by enabling more sophisticated assessment of cell and tissue microstructure in living patients.</p> <p>Metalenses based on flat optics are a game changing new technology because the control of image distortions necessary for high resolution imaging is straightforward compared to conventional optics, which requires multiple complex shaped lenses, said Federico Capasso, the Robert L. Wallace Professor of Applied Physics and Vinton Hayes Senior Research Fellow in Electrical Engineering at SEAS and co-senior author of the paper. I am confident that this will lead to a new class of optical systems and instruments with a broad range of applications in many areas of science and technology</p> <p>The versatility and design flexibility of the nano-optic endoscope significantly elevates endoscopic imaging capabilities and will likely impact diagnostic imaging of internal organs, said Hamid Pahlevaninezhad, Instructor in Medicine at MGH and HMS and co-first author of the paper. We demonstrated an example of such capabilities to achieve high-resolution imaging at greatly extended depth of focus.</p> <p>To demonstrate the imaging quality of the nano-optic endoscope, the researchers imaged fruit flesh, swine and sheep airways, and human lung tissue. The team showed that the nano-optic endoscope can image deep into the tissue with significantly higher resolution than provided by current imaging catheter designs.</p> <p>The images captured by the nano-optic endoscope clearly show cellular structures in fruit flesh and tissue layers and fine glands in the bronchial mucosa of swine and sheep. In the human lung tissue, the researchers were able to clearly identify structures that correspond to fine, irregular glands indicating the presence of adenocarcinoma, the most prominent type of lung cancer.</p> <p>Currently, we are at the mercy of materials that we have no control over to design high resolution lenses for imaging,' said Yao-Wei Huang, a postdoctoral fellow at SEAS and co-first author of the paper. The main advantage of the metalens is that we can design and tailor its specifications to overcome spherical aberrations and astigmatism and achieve very fine focus of the light. As a result, we achieve very high resolution with extended depth of field without the need for complex optical components.</p> <p>Next, researchers aim to explore other applications for the nano-optic endoscope, including a polarization-sensitive nano-optic endoscope, which could contrast between tissues that have highly-organized structures, such as smooth muscle, collagen and blood vessels.</p> </html>",
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      "body": "<html> <p>Inverse problem solving isn't a new technique in classical physics, but this algorithm represents one of the first successful examples of an inverse problem solving method with quantum materials. And it could make searching for interesting physics a more streamlined and deliberate process for many scientists. More physicists are working in condensed matter than any other subfield of physics -- the rich diversity of condensed matter systems and phenomena provide ample unsolved problems to explore, from superconductivity and superfluidity to magnetism and topology. Experimentalists probe the macro-and microscopic properties of materials to observe the behavior and interactions of particles in materials under a strict set of controls. Theoretical condensed matter physicists, on the other hand, work to develop mathematical models that predict or explain the fundamental laws that govern these behaviors and interactions.</p> <p>The field of theoretical condensed matter physics has the well-earned reputation for being esoteric and difficult for the lay person to decipher, with its focus on understanding the quantum mechanics of materials. The process of writing and solving condensed matter equations is extremely intricate and meticulous. That process generally starts with a Hamiltonian -- a mathematical model that sums up the energies of all the particles in the system.</p> <p>Clark explains, 'For a typical condensed matter problem, you start with a model, which comes out as a Hamiltonian, then you solve it, and you end up with a wave function -- and you can see the properties of that wave function and see whether there is anything interesting. This algorithm inverts that process. Now, if you know the desired type of physics you would like to study, you can represent that in a wave function, and the algorithm will generate all of the Hamiltonians -- or the specific models -- for which we would get that set of properties. To be more exact, the algorithm gives us Hamiltonians with that wave function as an energy eigenstate.'</p> <p><br></p> <p><em>Clark says the algorithm gives a new way to study physical phenomena such as superconductivity.</em></p> <p>'Typically, you would guess Hamiltonians that are likely to be superconducting and then try to solve them. What this algorithm -- in theory -- will allow us to do is to write down a wave function that we know superconducts and then automatically generate all of the Hamiltonians or the specific models that give that wave function as their solution. Once you have the Hamiltonians, in some sense, that gives you all the other properties of the system -- the excitation spectrum, all the finite temperature properties.</p> <p>That requires some more steps once you have the Hamiltonian, so we didn't improve that part of the research process. But what we did, we found a way to find interesting models, interesting Hamiltonians.'</p> <p>Chertkov adds, 'There are lots of wave functions people have written down for which there are no known Hamiltonians -- maybe 50 years worth. Now we can take any of these wave functions and ask if any Hamiltonians give those as eigenstates and you may end up with one model, no models, or many. For example, we are interested in spin-liquid wave functions, highly entangled quantum states with interesting topological properties.</p> <p><br></p> <p><em>Theorists have constructed many spin-liquid wave functions, but don't know which Hamiltonians give them.</em></p> <p><br></p> <p><code>In the future, our algorithm should let us find these Hamiltonians.'</code></p> <p><br></p> <p>Clark and Chertkov tested the algorithm on wave functions related to frustrated magnetism, a topic that presents interesting physics with many open questions. Frustrated magnetism occurs in a class of materials that is insulating, so the electrons don't move around, but their spins interact. Clark explains one such wave function they tested, 'The electron spins in a frustrated magnet want to be anti-aligned, like the north and south on a magnet, but can't because they live on triangles. So we make a wave function out of a linear-superposition of all of these frustrated states and we turn the crank of this algorithm, and ask, given this wavefunction, which is an interesting quantum state on a frustrated magnet, are there</p> <p><br></p> <p><code>Hamiltonians that would give it. And we found some.'</code></p> <p><br></p> <p>Chertkov says the results of the algorithm could point experimentalists in the right direction to find interesting new physics: 'That would hopefully be one way it would be used. You pick a wave function that has some kind of physics that you care about and you see what sort of interactions can give you that sort of physics, and hopefully then the models you find through this method can be looked for in experiments. And it turns out you find many models with our method.'</p> <p>Clark sums up, 'This has inverted the part of the process where we were sort of hunting in the dark. Before, you could say, we're going to try lots of models until we find something interesting. Now you can say, this is the interesting thing we want, let's turn the crank on this algorithm and find a model that gives that.'</p> </html>",
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