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      "author": "steemitboard",
      "body": "Congratulations @heady! You received a personal award!\n\n<table><tr><td>https://steemitimages.com/70x70/http://steemitboard.com/@heady/birthday2.png</td><td>Happy Birthday! - You are on the Steem blockchain for 2 years!</td></tr></table>\n\n<sub>_You can view [your badges on your Steem Board](https://steemitboard.com/@heady) and compare to others on the [Steem Ranking](https://steemitboard.com/ranking/index.php?name=heady)_</sub>\n\n\n**Do not miss the last post from @steemitboard:**\n<table><tr><td><a href=\"https://steemit.com/steemfest/@steemitboard/steemfest-commemorative-badge-refactored\"><img src=\"https://steemitimages.com/64x128/https://files.steempeak.com/file/steempeak/arcange/YqQV5Tbj-image.png\"></a></td><td><a href=\"https://steemit.com/steemfest/@steemitboard/steemfest-commemorative-badge-refactored\">SteemFest⁴  commemorative badge refactored</a></td></tr></table>\n\n###### [Vote for @Steemitboard as a witness](https://v2.steemconnect.com/sign/account-witness-vote?witness=steemitboard&approve=1) to get one more award and increased upvotes!",
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      "author": "therawtruth",
      "body": "I have been using NEXO since December2018 ! I have had a very good experience thus far. Although you do have to put in twice as much as you borrow, this is probably a good idea because markets are volatile and you need extra backing to avoid your assets being liquidated. Also the interest is very reasonable especially since they do pay dividends. And also if store stable coins with them you can earn interest unparalleled by any other bank.",
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      "body": "Hi hanen, this my entry to the contest..\nMe and my lovely jessy....\n![IMG_20180513_121936_490.jpg](https://steemitimages.com/DQmcpczffSPudZ1ac3ucU7h1maURBdsFtAqxgTZ2WJwvvop/IMG_20180513_121936_490.jpg)\n![IMG_20180513_121953_632.jpg](https://steemitimages.com/DQmPPj8F1kk4RKEU8a2ZND9TQ6pcqnSmjxKwiF4xdpnFkgf/IMG_20180513_121953_632.jpg)\n![IMG_20180513_122008_128.jpg](https://steemitimages.com/DQmYTvriJS1qPubA6xCoWf3bigihwzib6W5TbWqaZDQqGdo/IMG_20180513_122008_128.jpg)",
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      "body": "![image](https://img.esteem.ws/z9kcc8p175.jpg)\nThe findings, published in Developmental cellular, underscore the extraordinary resilience and plasticity of most cancers cells.\n\nSuch plasticity can presumably permit tumors to increase drug resistance, arguably the most important venture to a success cancer treatment.\n\n>most cancers cells will do some thing it takes to survive, says Purushothama Rao Tata,\n lead study author and assistant professor of cellular biology at Duke university faculty of medicine and a member of the Duke cancer Institute.\n\n>Upon remedy with chemotherapy, lung cells close down a number of the important thing mobile regulators and choose up the traits of other cells if you want to advantage resistance.\n\nTata has spent most of his profession reading the cellular kinds that make up normal lung tissue and the way those cells show flexibility at some point of regeneration following an damage.\n\n\nTata started out to wonder whether or not a number of the same rules that he had observed governing the regular development and regeneration of tissues may additionally be answerable for the jumbled nature of tumor cells.\n\nHe determined to recognition on non-small mobile lung most cancers, which accounts for eighty to 85 percent of all lung cancer cases.\n\nLung most cancers is the main purpose of cancer deaths international, and has one of the lowest survival quotes among all cancers.\n\nTata analyzed information from the most cancers Genome Atlas research community, a massive consortium that has profiled the genomes of heaps of samples from 33 exceptional forms of most cancers.\n\nHe determined that a big percentage of non-small cellular lung most cancers tumors lacked NKX2-1, a gene acknowledged to specify the lung lineage.\n\nalternatively, a lot of them expressed a number of genes associated with esophagus and gastrointestinal organs.\n\nwithin the absence of NKX2-1, Tata hypothesized, lung tumor cells would lose their lung identification and take at the traits of different cells.\n\ndue to the fact for the duration of improvement lung cells and intestine cells are derived from the same figure, or progenitor, cells, it made feel that after the lung cells misplaced their manner they would comply with the path of their nearest developmental sibling.\n\n\nto test whether or not this become the case, Tata and his colleagues generated distinct mouse models. First, they knocked out the NKX2-1 gene within the lung tissue of mice.\n\nunderneath the microscope, they noticed functions that usually best appear in the gut, inclusive of crypt-like structures and gastric tissues. Amazingly, these structures produced digestive enzymes, as though they resided within the belly and no longer the lung.\n\nHaving proven that a easy genetic tweak could prompt lung cells to interchange developmental tracks, Tata questioned if another tweak or  should gasoline them to shape tumors. This time, similarly to knocking out NKX2-1, they activated the oncogenes SOX2 or KRAS.\n\nThe group found that mice with the superimposed SOX2 mutations evolved tumors that looked as though they belonged within the foregut; people with KRAS mutations advanced tumors that resembled components of the mid- and hindgut.\n\nTata and associates then desired to realize if those genes have been sufficient to alter the destiny of lung cells, or if they needed extra signals from their local microenvironment.\n\nto reply this question, they developed a novel \"mini-lung tumoroid\" device—miniaturized variations of lung tumor tissue—and located that manipulation of genetics became sufficient for the lung cells to expose such plasticity.\n\n\n>cancer biologists have lengthy suspected that cancer cells ought to shape shift if you want to evade chemotherapy and acquire resistance, but they did not understand the mechanisms in the back of such plasticity, says Tata.\n\n>Now that we recognise what we are coping with in these tumors – we will think ahead to the possible paths these cells may take and layout therapies to dam them.\n\nwithin the destiny, Tata plans to apply his mini-lung tumoroid machine to similarly discover the mechanisms of resistance in lung cancer cells.\n\nThe big apple Stem mobile basis, the country wide Institutes of health/countrywide heart, Lung, and Blood Institute Early career research New college (P30) award, the Harvard Ludwig most cancers middle, the Massachusetts Eye and Ear Infirmary, a Harvard Stem cell Institute Junior Investigator grant, an NIH MSTP education supply, the scientific Scientist schooling application, an NIH/NHLBI career development Award, the Whitehead student application, the Maroni research pupil program, and the HHMI faculty pupil program funded the work.",
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      "body": "![image](https://img.esteem.ws/z9kcc8p175.jpg)\nThe findings, published in Developmental cellular, underscore the extraordinary resilience and plasticity of most cancers cells.\n\nSuch plasticity can presumably permit tumors to increase drug resistance, arguably the most important venture to a success cancer treatment.\n\n>most cancers cells will do some thing it takes to survive, says Purushothama Rao Tata,\n lead study author and assistant professor of cellular biology at Duke university faculty of medicine and a member of the Duke cancer Institute.\n\n>Upon remedy with chemotherapy, lung cells close down a number of the important thing mobile regulators and choose up the traits of other cells if you want to advantage resistance.\n\nTata has spent most of his profession reading the cellular kinds that make up normal lung tissue and the way those cells show flexibility at some point of regeneration following an damage.\n\n\nTata started out to wonder whether or not a number of the same rules that he had observed governing the regular development and regeneration of tissues may additionally be answerable for the jumbled nature of tumor cells.\n\nHe determined to recognition on non-small mobile lung most cancers, which accounts for eighty to 85 percent of all lung cancer cases.\n\nLung most cancers is the main purpose of cancer deaths international, and has one of the lowest survival quotes among all cancers.\n\nTata analyzed information from the most cancers Genome Atlas research community, a massive consortium that has profiled the genomes of heaps of samples from 33 exceptional forms of most cancers.\n\nHe determined that a big percentage of non-small cellular lung most cancers tumors lacked NKX2-1, a gene acknowledged to specify the lung lineage.\n\nalternatively, a lot of them expressed a number of genes associated with esophagus and gastrointestinal organs.\n\nwithin the absence of NKX2-1, Tata hypothesized, lung tumor cells would lose their lung identification and take at the traits of different cells.\n\ndue to the fact for the duration of improvement lung cells and intestine cells are derived from the same figure, or progenitor, cells, it made feel that after the lung cells misplaced their manner they would comply with the path of their nearest developmental sibling.\n\n\nto test whether or not this become the case, Tata and his colleagues generated distinct mouse models. First, they knocked out the NKX2-1 gene within the lung tissue of mice.\n\nunderneath the microscope, they noticed functions that usually best appear in the gut, inclusive of crypt-like structures and gastric tissues. Amazingly, these structures produced digestive enzymes, as though they resided within the belly and no longer the lung.\n\nHaving proven that a easy genetic tweak could prompt lung cells to interchange developmental tracks, Tata questioned if another tweak or  should gasoline them to shape tumors. This time, similarly to knocking out NKX2-1, they activated the oncogenes SOX2 or KRAS.\n\nThe group found that mice with the superimposed SOX2 mutations evolved tumors that looked as though they belonged within the foregut; people with KRAS mutations advanced tumors that resembled components of the mid- and hindgut.\n\nTata and associates then desired to realize if those genes have been sufficient to alter the destiny of lung cells, or if they needed extra signals from their local microenvironment.\n\nto reply this question, they developed a novel \"mini-lung tumoroid\" device—miniaturized variations of lung tumor tissue—and located that manipulation of genetics became sufficient for the lung cells to expose such plasticity.\n\n\n>cancer biologists have lengthy suspected that cancer cells ought to shape shift if you want to evade chemotherapy and acquire resistance, but they did not understand the mechanisms in the back of such plasticity, says Tata.\n\n>Now that we recognise what we are coping with in these tumors – we will think ahead to the possible paths these cells may take and layout therapies to dam them.\n\nwithin the destiny, Tata plans to apply his mini-lung tumoroid machine to similarly discover the mechanisms of resistance in lung cancer cells.\n\nThe big apple Stem mobile basis, the country wide Institutes of health/countrywide heart, Lung, and Blood Institute Early career research New college (P30) award, the Harvard Ludwig most cancers middle, the Massachusetts Eye and Ear Infirmary, a Harvard Stem cell Institute Junior Investigator grant, an NIH MSTP education supply, the scientific Scientist schooling application, an NIH/NHLBI career development Award, the Whitehead student application, the Maroni research pupil program, and the HHMI faculty pupil program funded the work.",
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      "body": "![image](https://img.esteem.ws/x2z90ed9n4.jpg)\nTrickling in through the giant radio dishes of NASA’s Deep space community, faint whispers from a distant robot explorer supply a message: I might not have lots time left.\n\nit is Voyager 1, our most remote explorer, nevertheless functioning and speaking with NASA because it speeds ever farther into deep area.\n\nThe message isn't a literal S.O.S. signal, however records from Voyager’s engine gadget alerting NASA engineers that a problem is on the horizon: Voyager can also soon lose the potential to align its radio dish — its verbal exchange lifeline — with Earth.\n\nlack of contact with Voyager would spell the stop of a more than 40-12 months career of discovery, an odyssey that started with the exploration of Jupiter and Saturn and continued in a long-distance quest to find the very fringe of interstellar area.\n\na long time ago the “grand tour” of Voyagers 1 and a couple of introduced us high-quality pictures and discoveries from Jupiter, Saturn, Uranus, Neptune and their moons.\nThey found out lively volcanoes on Io, hinted at a massive liquid-water ocean below Europa’s ice crust, and piqued our interest for Saturn’s mysterious, cloud-shrouded Titan. They showed us beautiful photos of Jupiter’s cloud belts and big hurricane systems, and opened our eyes to extraordinary information of Saturn’s jewelry.\n\nAfter traveling greater than 13 billion miles, Voyager 1 has best these days crossed that threshold beyond the reach of our solar and entered interstellar area. With a enormous, unexplored realm laid out beforehand, an untimely end to Voyager’s venture now might be a splendid loss. Scientists are hungry to research extra approximately what lies between the stars of our galaxy.\n\nVoyager 1’s test Engine light came On\n\nIt become inevitable that at some point, Voyager 1’s potential to hold in touch might begin to fade. running any such far flung area observatory presents numerous technical challenges, not the least of which is preserving radio communications over exceptional distance. NASA does this by keeping Voyager’s foremost radio dish aligned with Earth and the massive radio dishes of NASA’s Deep space community.\n\nLeft to its own inertia, the spacecraft could slowly rotate out of alignment, reacting to the subtle however persistent forces of factors like pressure from sunlight and the sun wind.\n\nthus far, Voyager 1 has used a fixed of “mindset control thrusters” that fire in tiny bursts to subtly steer the spacecraft to hold alignment. however over the last few years, NASA has observed that these thrusters are degrading, generating much less and much less thrust and requiring longer bursts to do their process.\n\nthe way to Take A Spaceship to the Mechanic\n\nYou don’t keep using your vehicle when the engine starts offevolved to sputter, if you plan to hold riding it. you are taking it to a mechanic.\n\nseeing that bringing Voyager in for a tune-up isn’t an option, NASA engineers needed to imagine a way to maintain Voyager’s project health using on-board resources. remember the fact that scene from Apollo 13 while the engineers needed to determine out a way for the astronauts to restore the carbon dioxide removal gadget using plastic baggage and duct tape?\n\nThe workaround for Voyager 1 become to try to reenlist a different set of engines that have been close down for 37 years.\n\nthose are Voyager’s “trajectory correction maneuver (TCM) thrusters.” They hadn’t been tested seeing that NASA engineers final used them to assist Voyager 1 maneuver through the Saturn gadget to make near flybys of the planet and its huge moon, Titan. as soon as the Saturn flyby was over, the TCM thrusters have been not wished, and have been close down.\n\nOn November 28, 2017, NASA sent the command to Voyager to check-hearth the TCM thrusters. That radio sign travelled thru space for 19.5 hours to attain Voyager (that’s now a long way away it is), even as NASA engineers waited.\n\nThen, after every other 19.5 hours of silence, NASA’s Goldstone radio antenna in the Mojave desert obtained word from Voyager 1 that the thrusters had fired!\n\nNASA now has a route ahead to preserve Voyager 1’s communication dish going through Earth for as a minimum some other  or three years, by using switching to the TCM machine as soon as the modern-day thrusters have gone off-line.\n\nThe Voyager Legacy\n\nlaunched in 1977,  Voyager 1’s number one assignment turned into to make flybys of the Jupiter and Saturn systems before being flung with the aid of Saturn’s gravity onto a course that might take it out of the sun machine, certain for interstellar space.\n\nNow, Voyager 1 is the maximum remote human-made object from Earth, and has been since it overtook the venerable Pioneer 10 in 1998. As of March 2018, Voyager 1 is over 13 billion miles away—or 141 instances further from the sun than Earth is.\n ![image](https://img.esteem.ws/luejxdn1fr.jpg)",
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