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      "body": "Hemoglobin is the protein inside red blood cells that carries oxygen. Red blood cells also remove carbon dioxide from your body, transporting it to the lungs for you to exhale. Red blood cells are made inside your bones, in the bone marrow. They typically live for about 120 days, and then they die. [1]\n<center>https://steemitimages.com/DQmXFbaFXgXDvstR32A5ep98darAN3E6YfxCrfg7JrWgbdU/lecture-17-14-638.jpg</center>\n<center>[Image credit](https://www.slideshare.net/RichardsonBio100/lecture-17-24598725)</center>\n\n## How Regulation of Blood Cell Production\nIn children the marrow of most bones produces blood cells.  By  adulthood,  however,  only  the  bones  of  the chest, the base of the skull, and the upper portions of the limbs remain active. The bone marrow in an adult weighs  almost  as  much  as  the  liver,  and  it  produces cells at an enormous rate.\n<center>https://steemitimages.com/DQmXPdLX8Rkr8J8P72E368CsMUBaDAoBAiorXLWpbCt6x3S/Hematopoiesis_simple.svg.png</center>\n</center>[Image credit](https://en.wikipedia.org)</center>\nAll blood cells are descended from a single population  of  bone  marrow  cells  called  pluripotent hematopoietic stem cells, which are undifferentiated cells capable of giving rise to precursors (progenitors) of any of the different blood cells. When a pluripotent stem cell divides, its two daughter cells either remain pluripotent stem cells or become committed to a particular  developmental  pathway;  what  governs  this “decision” is not known. \n\n**The first branching yields either lymphoid stem cells, which give rise to the lymphocytes, or so called myeloid stem cells, the progenitors  of  all  the  other  varieties**. At  some point, the proliferating offspring of the myeloid stem cells become committed to differentiate along only one path, for example into erythrocytes.\n\nProliferation and differentiation of the various progenitor cells is stimulated, at multiple points, by a large number of protein hormones and paracrine agents collectively  termed  hematopoietic  growth  factors (HGFs). Thus, erythropoietin, the hormone described earlier,  is  an  HGF.  (Nomenclature  can  be  confusing  in  this area since the HGFs belong to a still larger general family  of  messengers  termed  “cytokines\". \n\n## Physiology  of hematopoietic  growth  factors \nThe  physiology  of  the  HGFs  is  very  complex  because (1) there are so many of them, (2) any given HGF is  often  produced  by  a  variety  of  cell  types  throughout the body, and (3) HGFs often exert other actions in addition  to  stimulating  blood cell  production.  There are, moreover, many interactions of the HGFs on particular bone marrow cells and processes. For example, although  erythropoietin  is  the  major  stimulator  of erythropoiesis, at least 10 other HGFs cooperate in theprocess.  Finally,  in  several  cases  the  HGFs  not  only stimulate differentiation and proliferation of progenitor  cells,  they  inhibit  the  usual  programmed  death of these cells.\n\nThe administration of specific HGFs is proving tobe  of  considerable  clinical  importance.  Examples  are the  use  of  erythropoietin  in  persons  having  a  deficiency of this hormone due to kidney disease, and the use  of  granulocyte  colony  stimulating  factor  (G-CSF) to  stimulate  granulocyte  production  in  individuals whose bone marrow has been damaged by anticancer drugs.\n\n#### Sources :\n\n[What Are Red Blood Cells](https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentID=34&ContentTypeID=160)\n\n[Blood_cell](https://en.wikipedia.org/wiki/Blood_cell)\n\n[Regulation of Blood Cell Production](https://www.ncbi.nlm.nih.gov/pubmed/8831423)\n\n[Regulation of Blood Cell](http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2010.195057/full)",
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      "body": "@@ -4301,16 +4301,18 @@\n hnique. \n+%0A%0A\n The pati\n@@ -5360,16 +5360,18 @@\n lecule. \n+%0A%0A\n Three-di\n",
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      "body": "When you experience a bone break (also known as a fracture), it’s important that the bone can heal properly in its original position. There are several treatments for a broken bone, and the one a doctor recommends is based upon several factors. These include how severe the break is and where it is. While some bones can heal by wearing a cast, others may require more invasive treatments, such as bone fracture repair.\n\nBone fracture repair is a surgery to fix a broken bone using metal screws, pins, rods, or plates to hold the bone in place. It’s also known as open reduction and internal fixation (ORIF) surgery.\n\nPURPOSE",
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