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      "body": "关于成年人是否会产生新的神经元一直存在争议。以前发表的一篇Nature论文称，我们一旦成人后，大脑海马体神经元似乎就“停产”了。然而，4月5日刊登在 Cell Stem Cell杂志上的一项新成果反驳了这一观点。\n\n\n![](https://steemitimages.com/DQmaWVKEiAnhiM7bfotDWNNNMLvc5UCJ46j8xopHtygpmkr/image.png)\n\n\n图片来源： Cell Stem Cell（DOI: http://sci-hub.tw/10.1016/j.stem.2018.03.015）\n\n这项题为“Human Hippocampal Neurogenesis Persists throughout Aging”的研究首次证实，健康的老年男性和女性能与年轻人产生一样多的新脑细胞。即便在他们研究的最老的大脑中，也有新脑细胞产生。\n\n具体来说，研究人员解剖了来自28位先前健康但突然死亡的个体的海马体，他们的年龄在14-79岁之间。这是科学家第一次在个体死亡后不久观察新形成的神经元和整个人类海马体内的血管状态。需要强调的是，研究者们已经确定，这些研究对象认知能力没有受损，且没有患抑郁症或服用抗抑郁药。因为，这些情况先前已被证实会影响新脑细胞的产生。\n\n![](https://steemitimages.com/DQmNNZkF95ZkveAa9L96DeQJNJ8vnbiFFTEata8yZCprpDH/image.png)\n\n图片来源： Cell Stem Cell\n\n该研究结果显示，老年人与年轻人具有相似的能力——可从祖细胞产生数以千计的海马体新神经元。同时，不同年龄的人的海马体具有相等的体积。不过，相比年轻人，老年人具有较低的血管化程度，且新神经元形成连接的能力较弱。\n\n论文的通讯作者兼第一作者、哥伦比亚大学神经生物学副教授Maura Boldrini说：“虽然我们在老年人中发现了相似数量的中间神经祖细胞（intermediate neural progenitors）和数以千计的未成熟神经元，但老年个人在大脑结构中形成的新血管较少，且具有较小的祖细胞池（a smaller pool of progenitor cells）。”\n\n据此，作者们推测，老年时期认知-情绪弹性（cognitive-emotional resilience）的降低可能是由“神经干细胞池较小、血管形成能力下降以及海马体内细胞间链接减少”所导致的。未来，他们将进一步研究如何通过激素、转录因子和其他细胞间通路来调控神经细胞的增殖、成熟和生存。",
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      "body": "在古希腊神话中，有一位名为墨涅莫辛涅（Mnemosyune）的女神，是十二泰坦神之一，掌管记忆。这位女神有九个美丽的女儿，专司文艺与科学，也是就我们现在常常提到的缪斯女神。古希腊人是把记忆当作文艺与科学之母来看的，没有记忆，就没有文艺和科学。\n\n \n\n同时，古希腊人也对“能记住事情”感到疑惑。记忆是怎样产生的呢？哲学家柏拉图是这样认为的：大脑对事物留下印象的方式应当与尖锐物体在蜡版上留下划痕一样，印象一旦形成，那么直到被磨平为止便会一直存在；被磨平之后，出现的新的光滑的表面则是记忆的对立面，也就是完全的遗忘。\n\n这段话与现代神经科学的发现时隔千百年，但虽不中亦不远矣。我们大脑中确实存在一块“蜡版”，或者更像是老师讲课时用的一块黑板。从外界获知的新记忆就像是老师的板书，记录在黑板上，要将这些记忆转化为持久的记忆，就需要我们把板书从黑板上摘抄到笔记本上。自然，脑中的“黑板”也和真正的黑板一样，是有大小限制的，写满了就要擦掉旧的，才能为新的挪出空间。\n\n \n\n这块黑板叫做海马，板书是神经元突触的连接，擦掉一切的则是令人沉醉的黑甜乡——睡眠。\n\n \n\n在清醒的时候，大脑突触之间连接往往是被增强的，这就需要在睡眠期间进行负向调控，不过睡眠对突触可塑性的具体影响尚且不清楚。近期，发表在顶级期刊《科学》上的一篇研究为我们揭开了睡眠与记忆之间的神秘关系。\n\n\n\n来自日本东京大学的池谷裕二（Yuji Ikegaya）和RIKEN脑科学研究所的藤泽茂义（Shigeyoshi Fujisawa）团队合作发现，在睡眠的主要状态、慢波状态下，一种名为尖波涟漪（sharp-wave ripples，SWR）的特殊脑电波正是突触负调控的关键。特异性沉默尖波涟漪阻止了突触的自发下调，并阻碍了新记忆的学习！",
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